domains / families / science / two-sample-mr-exposure-screening-reference-grounded

two-sample-mr-exposure-screening-reference-grounded

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Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

When to use

• two-sample Mendelian randomization research designs
• exposure screening panels
• IVW-primary estimation
• complementary estimators
• sensitivity analyses
• multivariable MR upgrades
• reverse-MR upgrades
• conservative evidence interpretation

When not to use

• clinical treatment recommendations
• patient-specific diagnosis
• prescribing
• individual-level genotype processing pipelines
• pure observational epidemiology with no genetic instruments
• one-sample MR as the central design
• non-biomedical requests
• off-topic requests

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