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bio-tumor-fraction-estimation

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Estimates circulating tumor DNA fraction from shallow whole-genome sequencing using ichorCNA. Detects copy number alterations via HMM segmentation and calculates ctDNA percentage. Requires 0.1-1x sWGS coverage. Use when quantifying tumor burden from liquid biopsy or monitoring treatment response.

When to use

• quantifying tumor burden from liquid biopsy
• monitoring treatment response
• estimating ctDNA tumor fraction
• detecting copy number alterations
• calculating ctDNA percentage
• batch processing sWGS samples
• parsing ichorCNA results

When not to use

• targeted panel data

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