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dual-disease-shared-transcriptome-biomarker-research-planner

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Generates complete dual-disease shared-transcriptome biomarker and hub-gene research designs from a user-provided disease pair and shared-biology direction. Always use this skill whenever a user wants to design, plan, or build a non-oncology two-disease transcriptome study centered on per-disease differential expression, shared-signal intersection or concordance, PPI-based hub-gene prioritization, diagnostic evaluation across both diseases, immune infiltration context, pathway interpretation, and optional orthogonal validation. Covers five study patterns (shared-DEG-first workflow, hub-gene-first shared-biomarker workflow, hybrid shared-biomarker compression workflow, immune-context shared-biomarker workflow, orthogonal validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...

When to use

• dual-disease shared-transcriptome biomarker research design
• per-disease differential expression analysis
• shared-signal intersection or concordance
• PPI-based hub-gene prioritization
• diagnostic evaluation across both diseases
• immune infiltration context
• pathway interpretation
• orthogonal validation workflow

When not to use

• clinical trial protocols
• dosing or prescribing
• patient-specific treatment recommendations
• pure scRNA-only studies
• MR-only studies
• GWAS-only studies
• proteomics-only studies
• single-disease requests

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