domains / families / science / tooluniverse-gwas-trait-to-gene

tooluniverse-gwas-trait-to-gene

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Discover genes associated with diseases and traits using GWAS data from the GWAS Catalog (500,000+ associations) and Open Targets Genetics (L2G predictions). Identifies genetic risk factors, prioritizes causal genes via locus-to-gene scoring, and assesses druggability. Use when asked to find genes associated with a disease or trait, discover genetic risk factors, translate GWAS signals to gene targets, or answer questions like "What genes are associated with type 2 diabetes?"

When not to use

• **Gene Mapping Uncertainty**
• Positional mapping assigns SNPs to nearest gene (may be incorrect)
• Fine-mapping available for only a subset of studies
• Intergenic variants difficult to map
• **Population Bias**
• Most GWAS in European populations
• Effect sizes may differ across ancestries
• Rare variants often under-represented

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