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bio-chipseq-super-enhancers

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Identifies super-enhancers from H3K27ac ChIP-seq data using ROSE and related tools. Use when studying cell identity genes, cancer-associated regulatory elements, or master transcription factor binding regions that cluster into large enhancer domains.

When to use

• Identify super-enhancers from H3K27ac ChIP-seq
• Stitch nearby enhancer peaks
• Rank by signal to find large regulatory domains
• Study cell identity genes
• Study cancer-associated regulatory elements
• Study master transcription factor binding regions
• Custom hockey stick analysis
• Calculate enhancer signal

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