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bio-clinical-databases-somatic-signatures

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Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.

When to use

• Extract mutational signatures from tumor samples
• Decompose somatic mutation catalogs into mutational signatures
• Identify DNA damage mechanisms
• Identify mutagenic processes in cancer genomes
• Fit to COSMIC signatures
• Extract de novo signatures
• Interpret signature etiologies

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