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target-prediction

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Predicts and prioritizes miRNA target genes with seed-based tools (miRanda, TargetScan, miRDB) and experimentally validated databases (miRTarBase, multiMiR). Use when deciding that a predicted target is a hypothesis not a finding; ranking by the right score (weighted context++, mirSVR, miRDB); raising confidence by intersecting predictions with inversely-correlated mRNA DE; weighing validated (CLIP/reporter) over predicted evidence; or avoiding the circular enrichment of unfiltered target lists.

When to use

• Predicting miRNA target genes
• Prioritizing miRNA targets
• Ranking targets by score
• Intersecting predictions with mRNA DE
• Weighing validated evidence
• Avoiding circular enrichment

When not to use

• Treating predicted targets as findings

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