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single-gene-oncology-reference-grounded-research-planner

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Generates complete conventional single-gene oncology research designs from a user-provided cancer context, target gene, and validation direction. Use when a study centers on a fixed candidate gene and needs expression, prognosis, clinicopathologic association, functional interpretation, immune context, genomic or epigenetic context, optional drug-response hypotheses, and orthogonal validation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

When to use

• single-gene oncology research design
• tumor-vs-normal expression comparison
• survival and clinicopathologic association
• pathway interpretation
• immune-context evaluation
• genomic or epigenetic context support
• drug-sensitivity hypotheses
• orthogonal validation

When not to use

• clinical treatment recommendations
• patient-specific diagnosis
• prescribing
• pure genome-wide discovery with no pre-specified lead gene
• pure single-cell-only studies with no conventional bulk or portal backbone
• pure wet-lab mechanistic studies with no bioinformatics integration
• non-biomedical or off-topic requests

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