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bio-single-cell-splicing

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Analyzes alternative splicing at single-cell resolution using BRIE2 for probabilistic PSI estimation or leafcutter2 for cluster-based analysis with NMD detection. Identifies cell-type-specific splicing patterns. Use when analyzing isoform usage in scRNA-seq or finding splicing differences between cell populations.

When to use

• analyzing isoform usage in scRNA-seq
• finding splicing differences between cell populations
• estimating per-cell PSI values
• detecting differential intron usage
• NMD-inducing splicing detection
• identifying cell-type-specific splicing events

When not to use

• using Whippet.jl

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