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multimodal-integration

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Integrate multimodal single-cell data (CITE-seq RNA+protein, 10x Multiome RNA+ATAC, unpaired/diagonal RNA+ATAC) and choose the right joint method. Use when classifying an integration task by anchor structure (paired vs unpaired), denoising CITE-seq ADT background before joint embedding, picking between WNN, totalVI, MultiVI, MOFA+, GLUE, or Seurat v5 bridge integration, or diagnosing why a modality dominates a joint clustering.

When to use

• Classifying integration task by anchor structure
• Denoising CITE-seq ADT background
• Picking between WNN, totalVI, MultiVI, MOFA+, GLUE, or Seurat v5 bridge
• Diagnosing modality dominance in joint clustering
• Integrating paired CITE-seq or 10x Multiome data
• Integrating unpaired/diagonal RNA+ATAC data
• Handling mosaic multi-omic data

When not to use

• Batch correction for same modality across different cells

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