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bio-sequence-similarity

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Find homologous sequences using iterative BLAST (PSI-BLAST), profile HMMs (HMMER), and reciprocal best hit analysis. Use when identifying orthologs, distant homologs, or protein family members where standard BLAST is not sensitive enough.

When to use

• identifying orthologs
• identifying distant homologs
• identifying protein family members
• PSI-BLAST searches
• HMMER profile searches
• reciprocal best hit analysis
• Delta-BLAST searches
• PHI-BLAST searches

When not to use

• standard BLAST

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