domains / families / science / bio-tcr-bcr-analysis-scirpy-analysis

bio-tcr-bcr-analysis-scirpy-analysis

separate

Analyze single-cell TCR and BCR data integrated with gene expression using scirpy. Use when working with 10x Genomics VDJ data alongside scRNA-seq or when integrating immune receptor information with cell state analysis.

When to use

• Integrate immune receptor clonotype data with scRNA-seq gene expression
• Joint analysis of clonal expansion and cell state
• Import single-cell VDJ annotations
• Identify cells with aberrant chain pairing
• Define clonotypes by CDR3 sequence identity
• Identify expanded clonotypes
• Calculate diversity metrics per group
• Compare clonotype sharing between groups

Skill page

Source