domains / families / science / interpro-database
interpro-database
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Query InterPro for protein family, domain, and functional site annotations. Integrates Pfam, PANTHER, PRINTS, SMART, SUPERFAMILY, and 11 other member databases. Use for protein function prediction, domain architecture analysis, evolutionary classification, and GO term mapping.
When to use
- **Protein function prediction**: What function(s) does an uncharacterized protein likely have?
- **Domain architecture**: What domains make up a protein, and in what order?
- **Protein family classification**: Which family/superfamily does a protein belong to?
- **GO term annotation**: Map protein sequences to Gene Ontology terms via InterPro
- **Evolutionary analysis**: Are two proteins in the same homologous superfamily?
- **Structure prediction context**: What domains should a new protein structure be compared against?
- **Pipeline annotation**: Batch-annotate proteomes or novel sequences
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