domains / families / science / protac-degraders

protac-degraders

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

When to use

• designing targeted protein degraders
• planning linker SAR
• predicting ternary complex stability
• building generative degrader workflows
• E3 ligase choice
• linker design
• cooperativity characterization
• DC50 / Dmax characterization

When not to use

• target ligand design
• linker-only enumeration
• generative linker design
• molecular glue discovery strategy

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