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tooluniverse-polygenic-risk-score

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Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics. Calculates genetic risk profiles, interprets PRS percentiles, and assesses disease predisposition across conditions including type 2 diabetes, coronary artery disease, and Alzheimer's disease. Use when asked to calculate polygenic risk scores, interpret genetic risk for complex diseases, build custom PRS from GWAS data, or answer questions like "What is my genetic predisposition to breast cancer?"

When to use

• calculate polygenic risk scores
• interpret genetic risk for complex diseases
• build custom PRS from GWAS data
• assess disease predisposition
• interpret PRS percentiles
• extract genome-wide significant variants
• build weighted PRS models
• calculate individual risk scores

When not to use

• diagnose disease
• replace clinical assessment or genetic counseling
• account for non-genetic factors
• provide treatment recommendations

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