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bio-immunoinformatics-neoantigen-prediction

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Identify tumor neoantigens from somatic mutations using pVACtools for personalized cancer immunotherapy. Predict mutant peptides that bind patient HLA and may elicit T-cell responses. Use when identifying vaccine targets or checkpoint inhibitor response biomarkers from tumor sequencing data.

When to use

• Identify tumor neoantigens from somatic mutations
• Predict mutant peptides that bind patient HLA
• Identify vaccine targets
• Identify checkpoint inhibitor response biomarkers
• Run pVACseq neoantigen prediction pipeline
• Annotate somatic VCF with transcript consequences
• Parse pVACseq results
• Prioritize neoantigens for vaccine design

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