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bio-clinical-databases-myvariant-queries

separate

Query myvariant.info API for aggregated variant annotations from multiple databases (ClinVar, gnomAD, dbSNP, COSMIC, etc.) in a single request. Use when annotating variants with clinical and population data from multiple sources simultaneously.

When to use

• Annotating variants with clinical and population data
• Querying single variants by HGVS, rsID, or gene/protein change
• Batch querying up to 1000 variants
• Searching variants by gene, clinical significance, or genomic region
• Extracting specific annotations like ClinVar classification or gnomAD frequency
• Converting batch results to pandas DataFrames
• Handling large variant sets with chunked queries

When not to use

• Detailed ClinVar queries
• gnomAD-specific frequency queries
• dbSNP rsID lookups

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