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bio-causal-genomics-pleiotropy-detection

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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instrum...

When to use

• Detecting horizontal pleiotropy
• Removing pleiotropic outlier instruments
• Testing for directional pleiotropy
• Verifying variant directionality
• Validating causal inference results
• Correcting MR estimates for pleiotropy

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