domains / families / science / bio-causal-genomics-mendelian-randomization

bio-causal-genomics-mendelian-randomization

separate

Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.

When to use

• Test whether an exposure causally affects an outcome
• Estimate causal effects from GWAS summary statistics
• Apply IVW, MR-Egger, weighted median, and MR-PRESSO methods
• Extract instruments for exposure
• Extract matching outcome data
• Harmonize allele directions
• Evaluate MR evidence through method comparison
• Test for heterogeneity and pleiotropy

Skill page

Source