domains / families / science / prognostic-biomarker-protocol-designer

prognostic-biomarker-protocol-designer

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Designs discovery, modeling, and validation workflows for prognostic biomarkers in biomedical and clinical research. Always use this skill when the user needs a prognostic biomarker study blueprint rather than a diagnostic test protocol, predictive biomarker design, treatment recommendation, or a completed manuscript. Focus on endpoint family, follow-up horizon, time scale, candidate marker strategy, model-building logic, risk stratification framework, and internal/external validation requirements. Do not invent cohort size, event rate, assay readiness, literature support, or validation access.

When to use

• prognostic biomarker study blueprint
• discovery, modeling, and validation workflows
• time-to-event endpoint design
• marker screening
• multivariable model development
• risk stratification framework
• internal and external validation requirements
• cohort backbone and follow-up structure

When not to use

• diagnostic test protocol
• predictive biomarker design
• treatment recommendation
• completed manuscript
• diagnostic accuracy workflow
• treatment-response or predictive biomarker workflow
• mechanistic experiment plan
• diagnostic test evaluation

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