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mechanism-to-validation-planner

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Extends a mechanistic or association-level biomedical finding into a staged validation pathway that moves from descriptive evidence toward stronger functional support, mechanistic specificity, and clinical relevance. Use this skill when a user has a pathway, biomarker, cell-state, target, mechanism, or association finding and needs to decide what should be validated next, in what order, and which evidence layers are necessary versus optional. Do not default to maximal validation stacks. Build a structured validation ladder with a primary route, stronger upgrade route, and optional extensions.

When to use

• planning staged biomedical validation pathways
• sequencing validation steps from descriptive to functional evidence
• identifying missing validation layers
• distinguishing necessary from optional validation steps
• designing evidence chains toward clinical relevance
• classifying finding types and claim strength

When not to use

• direct wet-lab protocols with procedural detail
• patient-specific medical advice or treatment decisions
• final literature answers rather than validation-path design
• non-biomedical planning requests

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