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bio-long-read-sequencing-clair3-variants

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Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.

When to use

• calling germline variants from ONT alignments
• calling germline variants from PacBio alignments
• identifying SNPs and small indels
• region-specific variant calling
• gVCF output for joint calling
• phased variant calling
• quality filtering of variants

When not to use

• PacBio CLR variant calling

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