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lancet-statistics

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Use to enforce The Lancet's clinical-statistics reporting — confidence intervals over bare P values, a pre-specified primary analysis, intention-to-treat with per-protocol sensitivity, multiplicity control for secondary endpoints, cautious pre-specified subgroup analyses with interaction tests, missing-data handling, and absolute plus relative effects.

When to use

• clinical-statistics reporting
• confidence intervals over bare P values
• pre-specified primary analysis
• intention-to-treat with per-protocol sensitivity
• multiplicity control for secondary endpoints
• pre-specified subgroup analyses with interaction tests
• missing-data handling
• absolute plus relative effects

When not to use

• reporting P values without confidence intervals or effect sizes
• reporting only relative effects when absolute effects change clinical message
• presenting per-protocol as primary analysis for superiority trials
• mining subgroups with separate within-subgroup P values without interaction tests

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