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bio-hi-c-analysis-hic-differential

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Compare Hi-C contact matrices between conditions to identify differential chromatin interactions. Compute log2 fold changes, statistical significance, and visualize differential contact maps. Use when comparing Hi-C contacts between conditions.

When to use

• Compare Hi-C contacts between conditions
• Compute log2 fold-change contact maps
• Identify statistically significant differential interactions
• Visualize changes in 3D genome organization
• Per-pixel statistical testing
• FDR correction

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