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gnomad-frequencies

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Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin max-credible-AF framework. Use when filtering rare variants, applying ACMG BS1/BA1, ranking genes by LoF intolerance, or selecting between v2 (GRCh37 + chrX/Y constraint) and v4 (GRCh38 + 807k samples).

When to use

• filtering rare variants
• applying ACMG BS1/BA1
• ranking genes by LoF intolerance
• selecting between gnomAD versions
• querying allele frequencies
• retrieving constraint metrics
• accessing SV/CNV/mtDNA catalogs
• interpreting LOEUF

When not to use

• cancer-cohort analysis
• chrX/Y constraint in v4

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