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tiledbvcf

combined

Efficient storage and retrieval of genomic variant data using TileDB. Scalable VCF/BCF ingestion, incremental sample addition, compressed storage, parallel queries, and export capabilities for population genomics. Stores and retrieves genomic variant calls with TileDB-VCF. Use for indexed single-sample VCF/BCF ingestion, incremental cohorts, region and sample queries, streaming results, allele statistics, QC, and VCF/BCF export locally or through TileDB Cloud.

When to use

• Learning TileDB-VCF concepts and workflows
• Prototyping genomics analyses and pipelines
• Working with small-to-medium datasets (< 1000 samples)
• Need incremental addition of new samples to existing datasets
• Require efficient querying of specific genomic regions across many samples
• Working with cloud-stored variant data (S3, Azure, GCS)
• Need to export subsets of large VCF datasets
• Building variant databases for cohort studies

When not to use

• Multi-sample VCF ingestion

Skill page

Conflict

The K-Dense-AI copy is a highly specific, version-pinned (0.40.3) procedure that includes critical coordinate system warnings (0-based vs 1-based) and specific ABI pins for macOS ARM64. The other two copies (Vibe-Skills and OpenClaw-Medical-Skills) are identical to each other and represent a more generic, older version of the skill that uses deprecated installation flags (CONDA_SUBDIR=osx-64) and lacks the coordinate safety checks. Because the K-Dense copy contains material steps (verification, specific pins) and constraints (coordinate conventions) that the others lack, and the others contain a different (older) installation path, crowning one would hide the alternative or the specific safety constraints.