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bio-microbiome-functional-prediction

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Predict metagenome functional content from 16S rRNA marker gene data using PICRUSt2. Infer KEGG, MetaCyc, and EC abundances from ASV tables. Use when functional profiling is needed from 16S data without shotgun metagenomics sequencing.

When to use

• Predict functional pathways from 16S data
• Infer metagenome functional content from marker gene ASV tables
• Infer KEGG, MetaCyc, and EC abundances
• Functional profiling from 16S data without shotgun metagenomics sequencing

When not to use

• Predictions based on phylogenetic placement
• Novel taxa (high NSTI) have unreliable predictions
• 16S resolution limits species-level accuracy
• Cannot detect horizontal gene transfer events

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