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pharmacogenomics

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Queries PharmGKB / CPIC / DPWG for drug-gene interactions; calls CYP2D6/CYP2C9/CYP2C19/DPYD/TPMT/NUDT15/UGT1A1/SLCO1B1 star alleles and phenotype with PharmCAT, Cyrius (CYP2D6 structural variants), Aldy, Stargazer; applies Caudle 2020 activity-score translation. Use when implementing pharmacogenomic-guided prescribing, applying CPIC vs DPWG guidance, screening HLA risk alleles for ICI / antiepileptics / abacavir, or interpreting compound TPMT+NUDT15 thiopurine risk.

When to use

• implementing pharmacogenomic-guided prescribing
• applying CPIC vs DPWG guidance
• screening HLA risk alleles for ICI / antiepileptics / abacavir
• interpreting compound TPMT+NUDT15 thiopurine risk
• calling CYP2D6/CYP2C9/CYP2C19/DPYD/TPMT/NUDT15/UGT1A1/SLCO1B1 star alleles
• determining CYP2D6 metabolizer status
• adjusting tamoxifen dose based on CYP2D6 status

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