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ligandmpnn

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Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.

When to use

• Designing sequences around small molecules
• Enzyme active site design
• Ligand binding pocket optimization
• Metal coordination site design
• Cofactor binding proteins
• DNA/RNA binding site design

When not to use

• Standard protein design
• Solubility optimization
• Protein-protein binder design
• De novo scaffold design

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