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bio-causal-genomics-colocalization-analysis

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Test whether two traits share a causal variant at a genomic locus using Bayesian colocalization with coloc. Computes posterior probabilities for shared vs distinct causal variants between GWAS and eQTL signals. Use when determining if a GWAS signal and an eQTL share the same causal variant.

When to use

• Test whether GWAS signal and eQTL share the same causal variant
• Compute Bayesian posterior probabilities for colocalization hypotheses
• Distinguish true causal overlap from LD-driven coincidence
• Test colocalization at loci with multiple independent causal signals
• Test colocalization across three or more traits simultaneously

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