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clinical-cohort-protocol-designer

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Designs retrospective or prospective clinical cohort study protocols for biomedical and clinical research. Always use this skill when the user needs a cohort-based study plan rather than a general study idea, evidence summary, or mechanistic experiment design. Focus on cohort appropriateness, enrollment logic, baseline time-zero definition, follow-up structure, endpoint definition, variable collection, confounding control, and a coherent primary statistical analysis line. Do not invent data availability, follow-up completeness, outcome ascertainment quality, sample size adequacy, or causal interpretability.

When to use

• retrospective or prospective clinical cohort study protocols
• cohort-based study plans
• cohort appropriateness assessment
• enrollment logic and baseline time-zero definition
• follow-up structure and endpoint definition
• variable collection and confounding control
• primary statistical analysis line design
• real-world evidence concepts involving routine clinical data

When not to use

• general study ideas
• evidence summaries
• mechanistic experiment designs
• generic research ideas
• mechanistic wet-lab plans
• completed manuscripts
• case-control design
• cross-sectional design

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