domains / families / science / adaptive-trial-simulator

adaptive-trial-simulator

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Design and simulate adaptive clinical trials with interim analyses, decision rules, and operating-characteristic summaries; use when planning adaptive designs or comparing stopping, enrichment, or sample-size re-estimation strategies.

When to use

• Use this skill when the task is to Design and simulate adaptive clinical trials with interim analyses.
• Use this skill for protocol design tasks that require explicit assumptions, bounded scope, and a reproducible output format.
• Use this skill when the response must stay inside the documented task boundary instead of expanding into adjacent work.

When not to use

• **Statistical Complexity**: Requires biostatistics expertise
• **Simulation Time**: Large simulations may take hours
• **Simplified Models**: Does not capture all real-world complexities
• **Regulatory Consultation**: Results should be validated with regulators
• Do not proceed when required input files, identifiers, parameters, or context are missing — ask the user to provide them first.
• Do not assume capabilities beyond this skill's declared scope when the user requests external operations or inferences.
• Do not proceed without user confirmation when overwriting existing results, executing high-cost batch operations, or expanding task scope.

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