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bio-causal-genomics-mediation-analysis

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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular...

When to use

• Decompose genetic effects into direct and indirect paths
• Test whether gene expression mediates variant effect on disease
• Test whether DNA methylation mediates variant effect
• Estimate ACME, ADE, and proportion mediated
• eQTL mediation analysis across multiple genes
• Multi-omics mediation chains
• Causal mediation analysis with bootstrap confidence intervals

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