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mendelian-randomization

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Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

When to use

• testing causal direction between traits
• evaluating drug-target effects via cis-pQTL/cis-eQTL
• performing multivariable mediation MR
• distinguishing causation from correlated horizontal pleiotropy
• producing STROBE-MR-compliant sensitivity batteries

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