domains / families / science / mediation-analysis

mediation-analysis

separate

Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.

When to use

• testing whether a molecular phenotype mediates a treatment-outcome relationship
• decomposing exposure-mediator interaction via VanderWeele 4-way
• screening high-dimensional EWAS mediators
• running MR-based mediation when sequential ignorability is implausible
• decomposing total effects into direct and indirect paths
• handling exposure-mediator interaction
• sensitivity to unmeasured confounding
• high-dimensional mediator screening

When not to use

• tasks where sequential ignorability is not assumed or tested
• non-mediation causal inference tasks

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