domains / families / science / causal-genomics-pipeline

causal-genomics-pipeline

separate

End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene prioritization (L2G / PoPS / cS2G), and GenomicSEM common-factor GWAS. Use when triangulating causal inference across multiple complementary methods, prioritizing tissues via stratified LDSC, nominating or de-risking drug targets, mapping a lead SNP to a candidate effector gene, modeling shared genetic architecture across correlated traits, or producing a STROBE-MR-compliant publication-grade evidence battery from GWAS summary statistics.

When to use

• triangulating causal inference across multiple complementary methods
• prioritizing tissues via stratified LDSC
• nominating or de-risking drug targets
• mapping a lead SNP to a candidate effector gene
• modeling shared genetic architecture across correlated traits
• producing a STROBE-MR-compliant publication-grade evidence battery
• orchestrating heritability partitioning and genetic-correlation diagnostics
• Mendelian randomization with CHP-aware sensitivity

Skill page

Source