domains / families / science / cbioportal-database

cbioportal-database

separate

Query cBioPortal for cancer genomics data including somatic mutations, copy number alterations, gene expression, and survival data across hundreds of cancer studies. Essential for cancer target validation, oncogene/tumor suppressor analysis, and patient-level genomic profiling.

When to use

• **Mutation landscape**: What fraction of a cancer type has mutations in a specific gene?
• **Oncogene/TSG validation**: Is a gene frequently mutated, amplified, or deleted in cancer?
• **Co-mutation patterns**: Are mutations in gene A and gene B mutually exclusive or co-occurring?
• **Survival analysis**: Do mutations in a gene associate with better or worse patient outcomes?
• **Alteration profiles**: What types of alterations (missense, truncating, amplification, deletion) affect a gene?
• **Pan-cancer analysis**: Compare alteration frequencies across cancer types
• **Clinical associations**: Link genomic alterations to clinical variables (stage, grade, treatment response)
• **TCGA/GENIE exploration**: Systematic access to TCGA and clinical sequencing datasets

Skill page

Source