domains / families / science / open-targets-db

open-targets-db

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Query the Open Targets Platform to retrieve targets, diseases, or evidence records when you need target-disease association data and evidence-based scores for therapeutic discovery.

When to use

• You have a disease (e.g., an EFO ID) and want to discover and prioritize candidate therapeutic targets.
• You have a target (e.g., an Ensembl gene ID) and need to review associated diseases and supporting evidence.
• You need evidence-level details (e.g., GWAS, ClinVar, ChEMBL) to justify or audit a target-disease association.
• You want to compare association strength across targets/diseases using Open Targets evidence scoring.
• You are building a pipeline that programmatically fetches curated target-disease associations from Open Targets.

When not to use

• Do not use this skill when the required source data, identifiers, files, or credentials are missing.
• Do not use this skill when the user asks for fabricated results, unsupported claims, or out-of-scope conclusions.
• Do not use this skill when a simpler direct answer is more appropriate than the documented workflow.

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