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polars-bio

separate

Performs genomic interval overlap, nearest, merge, coverage, complement and subtraction on Polars DataFrames, and reads or writes BED, VCF, BCF, BAM, CRAM, GFF, GTF, FASTA and FASTQ data. Use for coordinate-aware genomic joins, read-depth analysis, lazy bioinformatics I/O, SQL queries or migration from bioframe.

When to use

• genomic interval overlap
• nearest neighbor analysis
• interval merge
• coverage analysis
• complement and subtraction
• reading and writing BED, VCF, BCF, BAM, CRAM, GFF, GTF, FASTA, FASTQ
• coordinate-aware genomic joins
• read-depth analysis

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