domains / families / science / bindcraft

bindcraft

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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

When to use

• Designing protein binders with built-in AF2 validation
• Running production-quality binder campaigns
• Using different design protocols (fast, default, slow)
• Joint backbone and sequence optimization
• Achieving high experimental success rate

When not to use

• Backbone-only generation
• QC thresholds
• Tool selection guidance

Skill page

Source