domains / families / science / consensus-peakset

consensus-peakset

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

When to use

• differential accessibility
• ML feature engineering
• cross-sample comparison
• fixed-width peak counts
• Corces 2018 iterative overlap
• DiffBind summit re-centering
• ENCODE consistency rules

When not to use

• quick exploratory analysis
• high-stringency reproducibility
• sub-501bp resolution
• broad peaks without summit info

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