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nejm-statistics

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Use to enforce NEJM's clinical statistical reporting — confidence intervals over bare P values, the pre-specified intention-to-treat primary analysis, multiplicity control for secondary endpoints, pre-specified subgroups with interaction tests, missing-data handling, and absolute risk with NNT alongside relative measures.

When to use

• confidence intervals over bare P values
• pre-specified intention-to-treat primary analysis
• multiplicity control for secondary endpoints
• pre-specified subgroups with interaction tests
• missing-data handling
• absolute risk with NNT alongside relative measures
• statistical reviewer preflight checks

When not to use

• reporting relative risk without absolute risk
• declaring secondary endpoints significant outside multiplicity plan
• inferring no effect from wide CI crossing null
• using causal verbs for observational associations

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