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jama-study-design

separate

Use when locking the study design and internal-validity safeguards for a JAMA clinical manuscript (RCT, cohort, diagnostic, or systematic review). Strengthens design choices; it does NOT pick the reporting checklist or run the statistics.

When to use

• Choosing or defending the design: RCT vs cohort vs case-control vs diagnostic
• A reviewer will ask whether the analysis is intention-to-treat or per-protocol
• Bias, confounding, or missing data threaten the primary inference
• The design and the reporting checklist need to be aligned before writing
• Locking the study design and internal-validity safeguards
• Strengthening design choices

When not to use

• pick the reporting checklist
• run the statistics

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