domains / families / research / ensembl-database

ensembl-database

combined

Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research. Access Ensembl REST API for vertebrate genomic data; use when you need gene/ID lookups, sequence retrieval, variant effect prediction (VEP), or homology/assembly coordinate mapping.

When to use

• Querying gene information by symbol or Ensembl ID
• Retrieving DNA, transcript, or protein sequences
• Analyzing genetic variants using the Variant Effect Predictor (VEP)
• Finding orthologs and paralogs across species
• Accessing regulatory features and genomic annotations
• Converting coordinates between genome assemblies (e.g., GRCh37 to GRCh38)
• Performing comparative genomics analyses
• Integrating Ensembl data into genomic research pipelines

Skill page

Conflict

The two copies overlap on Ensembl REST use cases (gene lookup, sequence, VEP, homology, assembly mapping) but each has material steps the other lacks. The aipoch copy is a packaged skill centered on scripts/query_ensembl.py with a CLI contract (--action lookup|sequence|vep, --species, --symbol, --id, --hgvs) and references/api_endpoints.md, but it omits rate-limiting, error handling, and direct REST examples. The FreedomIntelligence copy provides direct REST endpoints, ensembl_rest Python examples, rate-limiting (15 req/s, Retry-After), error handling, and assembly-mapping server selection, but it does not define the packaged CLI or the repository's script-based execution path. Crowning one would hide a real alternative workflow.