domains / families / data / lollipop-protein-maps

lollipop-protein-maps

separate

Plot per-gene mutation distributions on a protein-domain map (lollipop / needle plots) showing mutation position, recurrence count, and variant classification with maftools, g3-lollipop, trackViewer, and ProteinPaint. Use when visualizing recurrent mutation hotspots on a single gene's protein, marking domain boundaries from UniProt/Pfam, comparing missense vs truncating distributions, or contrasting two cohorts on the same lollipop.

When to use

• visualizing recurrent mutation hotspots
• marking domain boundaries from UniProt/Pfam
• comparing missense vs truncating distributions
• contrasting two cohorts on the same lollipop
• rendering per-gene mutation distribution
• identifying hotspot residues
• adding ClinVar / OncoKB level annotation

When not to use

• 3D-cluster hotspot detection
• HotMAPS / 3D Hotspots

Skill page

Source